Please find below a list of currently open research studies at our CRF.
Capturing multi-organ effects of COVID-19.
The COVID-19 Clinical Neuroscience Study.
► Dementia and cognitive impairment
Deep and Frequent Phenotyping: Combinatorial Biomarkers for Dementia Experimental Medicine.
DPUK Tau (PREVENT Sub study)
Assessing Models of AD risk and progression in existing cohorts using Tau PET imaging in combination with prospective follow-up.
ENCRYPT (PREVENT Sub study)
The Entorhinal CoRtex-hippocampal circuit in PREVENT (ENCRYPT) study.
Impact of Semaglutide in Amyloid Positivity: The ISAP Proof of Concept Study.
A study to characterise C9orf72 patients and asymptomatic carriers.
New Therapeutics in Alzheimer’s Disease – MEG biomarker platform development.
Previous research suggests there can be a variety of markers of dementia before the presentation of symptoms. The Prevent study aims to investigate participants between the ages of 40 and 59 years old in their exposure to risk factors before dementia onset. It is a longitudinal and cross-sectional study which means that the study is ongoing and will take a snapshot of participants at consecutive 2 – 6-year time gaps throughout their middle age. At each of these visits, a series of assessments are carried out to investigate a wide range of risk factors, including cognitive performance, biomarkers, and brain structural/functional changes. The study is thorough, aiming to identify any other risk factors with possible links to dementia onset, including a family history of dementia, life stressors, drug use, alcohol intake, sleep quality, exposure to contact sports and physical activity. The study has been running at the Clinical Research Facility (CRF) since 2017, and participants will be coming up to their 3rd visit as we approach 2023. The CRF is incredibly grateful to all Prevent participants who have already volunteered their time and contributed so much to the trial.
Remote assessment of Disease and Relapse – Alzheimer’s Disease.
► Healthy volunteers
Reward, Emotion, Learning, and Ketamine study.
Analysing Patients’ Facial Expressions to improve Mood Assessment.
Glutamate Emotion Memory Study (GEMS)
Does modulation of glutamate transmission in the brain using a sub-anaesthetic dose of ketamine affect autobiographical memory, emotional processing and decision-making in treatment-resistant depression?
This study aims to find out whether seltorexant (JNJ-42847972) could be used as an add-on treatment, along with your current anti-depressant medication, to treat depression (Major Depressive Disorder) that has not responded to current antidepressant medication (SSRI) and psychotherapy.
Lithium and quetiapine for treatment resistant depression.
Randomised, placebo-controlled trial evaluating the efficacy and mechanism of Pramipexole as add-on treatment for people with treatment resistant depression.
An open-label long-term extension safety study of intranasal esketamine in treatment-resistant depression safety and sustenance of esketamine treatment response with repeated doses at intervals determined by symptom severity (SUSTAIN-3).
A study to evaluate the effect of ALKS 3831 compared to olanzapine on body weight in young adults with schizophrenia, schizophreniform, or bipolar I disorder who are early in their illness.
The Physical and menTal healTH – ExploRatioN study.
A randomised phase II double-blinded placebo-controlled trial of intravenous immunoglobulins and rituximab in patients with antibody-associated psychosis.