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You are here: Home / Research Themes / Informatics and Digital Health / Recent publications – Informatics and Digital Health

Recent publications – Informatics and Digital Health


Breilmann J, Girlanda F, Guaiana G, Barbui C, Cipriani A, Castellazzi M, Bighelli I, Davies SJ, Furukawa TA, Koesters M. Benzodiazepines versus placebo for panic disorder in adults. Cochrane Database Syst Rev. 2019 Mar 28;3:CD010677.


Atkinson LZ, Colbourne L, Smith A, Harmer CH, Nobre AC, Rendell J, Jones H, Hinds C, Mould A, Tunbridge EM, Cipriani A, Geddes JR, Saunders KEA, Harrison PJ. The Oxford study of Calcium channel Antagonism, Cognition, Mood instability and Sleep (OxCaMS): study protocol for a randomised controlled, experimental medicine study. Trials. 2019 Feb 12;20(1):120.


Bighelli I, Castellazzi M, Cipriani A, Girlanda F, Guaiana G, Koesters M, Turrini G, Furukawa TA, Barbui C. Antidepressants versus placebo for panic disorder in adults. Cochrane Database Syst Rev. 2018 Apr 5;4:CD010676.


Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, Leucht S, Ruhe HG, Turner EH, Higgins JP, Egger M. Comparative efficacy and acceptability of antidepressant drugs in the acute treatment of major depressive disorder: A network meta-analysis. Lancet. 2018 Feb 5.


Cipriani A, Cowen PJ. 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for post-traumatic stress disorder in service personnel. Lancet Psychiatry. 2018 Jun;5(6):453-455. 


Cipriani A, Salanti G, Furukawa TA, Egger M, Leucht S, Ruhe HG, Turner EH, Atkinson LZ, Chaimani A, Higgins JPT, Ogawa Y, Takeshima N, Hayasaka Y, Imai H, Shinohara K, Tajika A, Ioannidis JPA, Geddes JR. Antidepressants might work for people with major depression: where do we go from here? Lancet Psychiatry. 2018 Jun;5(6):461-463


Cipriani A, Tomlinson A. Providing the most appropriate care to our individual patients. Evid Based Ment Health. 2019 Feb;22(1):1-2.


Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, Leucht S, Ruhe HG, Turner EH, Higgins JPT, Egger M, Takeshima N, Hayasaka Y, Imai H, Shinohara K, Tajika A, Ioannidis JPA, Geddes JR. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. Lancet. 2018 Apr 7;391(10128):1357-1366.


Cipriani A, Williams T, Nikolakopoulou A, Salanti G, Chaimani A, Ipser J, Cowen PJ, Geddes JR, Stein DJ. Comparative efficacy and acceptability of pharmacological treatments for post-traumatic stress disorder in adults: a network meta-analysis. Psychol Med. 2018 Sep;48(12):1975-1984.


Cortese S, Tomlinson A, Cipriani A. Meta-Review: Network Meta-Analyses in Child and Adolescent Psychiatry. Journal of the American Academy of Child and Adolescent Psychiatry. 2019 Feb;58(2):167-79.


Cortese S, Adamo N, Del Giovane C, Mohr-Jensen C, Hayes AJ, Carucci S, Atkinson LZ, Tessari L, Banaschewski T, Coghill D, Hollis C, Simonoff E, Zuddas A, Barbui C, Purgato M, Steinhausen HC, Shokraneh F, Xia J, Cipriani A. Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis. Lancet Psychiatry. 2018 Sep;5(9):727-738.


Cuijpers P, Noma H, Karyotaki E, Cipriani A, Furukawa TA. Effectiveness and Acceptability of Cognitive Behavior Therapy Delivery Formats in Adults With Depression: A Network Meta-analysis. JAMA Psychiatry. 2019 Jul 1;76(7):700-707.


Davies C, Radua J, Cipriani A, Stahl D, Provenzani U, McGuire P, Fusar-Poli P. Efficacy and Acceptability of Interventions for Attenuated Positive Psychotic Symptoms in Individuals at Clinical High Risk of Psychosis: A Network Meta-Analysis. Front Psychiatry. 2018 Jun 12;9:187.


Davies C, Cipriani A, Ioannidis JPA, Radua J, Stahl D, Provenzani U, McGuire P, Fusar-Poli P. Lack of evidence to favor specific preventive interventions in psychosis: a network meta-analysis. World Psychiatry. 2018 Jun;17(2):196-209.


De Crescenzo F, Ciabattini M, D’Alò GL, De Giorgi R, Del Giovane C, Cassar C, Janiri L, Clark N, Ostacher MJ, Cipriani A. Comparative efficacy and acceptability of psychosocial interventions for individuals with cocaine and amphetamine addiction: A systematic review and network meta-analysis. PLoS Med. 2018 Dec 26;15(12):e1002715.


Del Giovane C, Cortese S, Cipriani A. Combining Pharmacological and Nonpharmacological Interventions in Network Meta-analysis in Psychiatry. JAMA Psychiatry. 2019 Apr 17.


Duffy A, Saunders KEA, Malhi GS, Patten S, Cipriani A, McNevin SH, MacDonald E, Geddes J. Mental health care for university students: a way forward? Lancet Psychiatry. 2019 Jul 16. pii: S2215-0366(19)30275-5.


Duffy A, Heffer N, Goodday SM, Weir A, Patten S, Malhi GS, Cipriani A. Efficacy and tolerability of lithium for the treatment of acute mania in children with bipolar disorder: A systematic review: A report from the ISBD-IGSLi joint task force on lithium treatment. Bipolar Disord. 2018 Nov;20(7):583-593.


Farhoult-Jepsen M, Geddes JR, Goodwin GM, Bauer M, Duffy A, Kessing L, Saunders KEA. Reporting guidelines on remotely collected electronic mood data in mood disorder (eMOOD) – Recommendations. Translational Psychiatry 9(1) 162


Furukawa TA, Cipriani A, Cowen PJ, Leucht S, Egger M, Salanti G. Optimal dose of selective serotonin reuptake inhibitors, venlafaxine, and mirtazapine in major depression: a systematic review and dose-response meta-analysis.Lancet Psychiatry. 2019 Jul;6(7):601-609.


Furukawa TA, Karyotaki E, Suganuma A, Pompoli A, Ostinelli EG, Cipriani A, Cuijpers P, Efthimiou O. Dismantling, personalising and optimising internet cognitive-behavioural therapy for depression: a study protocol for individual participant data component network meta-analysis. BMJ Open. 2019 Feb 22;8(11):e026137.


Furukawa TA, Maruo K, Noma H, Tanaka S, Imai H, Shinohara K, Ikeda K, Yamawaki S, Levine SZ, Goldberg Y, Leucht S, Cipriani A. Initial severity of major depression and efficacy of new generation antidepressants: individual participant data meta-analysis. Acta Psychiatr Scand. 2018 Jun;137(6):450-458.


Furukawa TA, Efthimiou O, Weitz ES, Cipriani A, Keller MB, Kocsis JH, Klein DN, Michalak J, Salanti G. Cuijpers P, Schramm E.  Cognitive-Behavioral Analysis System of Psychotherapy, Drug, or Their Combination for Persistent Depressive Disorder: Personalizing the Treatment Choice Using Individual Participant Data Network Metaregression. Psychother Psychosom. 2018;87(3):140-153.


Furukawa TA, Cipriani A, Leucht S, Atkinson LZ, Ogawa Y, Takeshima N, Hayasaka Y, Chaimani A, Salanti G. Is placebo response in antidepressant trials rising or not? A reanalysis of datasets to conclude this long-lasting controversy. Evid Based Ment Health. 2018 Feb;21(1):1-3.


Gillett, G, Saunders KEA. Remote monitoring for understanding mechanisms and prediction in psychiatry. Current Behavioural Neuroscience Reports. 2019

Gligic, L., Kormilitzin, A., Goldberg, P. and Nevado-Holgado, A. (2020). Named entity recognition in electronic health records using transfer learning bootstrapped Neural Networks. Neural Networks, [online] 121, pp.132–139.


Gobbi G, Atkin T, Zytynski T, Wang S, Askari S, Boruff J, Ware M, Marmorstein N, Cipriani A, Dendukuri N, Mayo N. Association of Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood: A Systematic Review and Meta-analysis. JAMA Psychiatry. 2019 Apr 1;76(4):426-434. 


Goodday SM, Cipriani A. Challenges in identifying behavioural markers of bipolar disorder through objective smartphone data. Aust N Z J Psychiatry. 2019 Feb;53(2):168-169.


Goodday S, Atkinson L, Goodwin G, Saunders K, South M, Mackay C, Denis M, Hinds C, Davies J, Welch J, Stevens W, Mansfield K, Suvilehto J, Geddes J. The True Colours remote symptom monitoring system: A decade of evolution Journal of Medical Internet Research. (forthcoming/in press)


Goodday SM, Rivera D, Foran, H, King N, Milanovic M, Keown-Stoneman C, Horrocks J, Tetzlaff E, Pickett W, Harkness, K, Bowie, C, Saunders K, Cunningham S, McNevin, S, Duffy A. The U-Flourish University Student Well-Being and Academic Success Longitudinal Survey: A Study Protocol. British Medical Journal Open. 2019


Goodday SM, Kormilitzin A, Vaci N, Liu Q, Cipriani A, Smith T, et al. Maximizing the use of social and behavioural information from secondary care mental health electronic health records. Journal of Biomedical Informatics. 2020 Jul;107:103429.


Gordon-Smith K, Saunders KEA, Geddes JR, Harrison PJ, Hinds C, Craddock N, Jones I. Large-scale roll out of electronic longitudinal mood-monitoring for research in affective disorders: report from the UK Bipolar Disorder Research Network. Journal of Affective Disorders. 2019  246:789-793 3


Henshall C, Cipriani A, Ruvolo D, Macdonald O, Wolters L, Koychev I. Implementing a digital clinical decision support tool for side effects of antipsychotics: a focus group study. Evid Based Ment Health. 2019 May;22(2):56-60.


Hidalgo-Mazzei D, Berk M, Cipriani A, Cleare AJ, Florio AD, Dietch D, Geddes JR, Goodwin GM, Grunze H, Hayes JF, Jones I, Kasper S, Macritchie K, McAllister-Williams RH, Morriss R, Nayrouz S, Pappa S, Soares JC, Smith DJ, Suppes T, Talbot P, Vieta E, Watson S, Yatham LN, Young AH, Stokes PRA. Treatment-resistant and multi-therapy-resistant criteria for bipolar depression: consensus definition. Br J Psychiatry. 2019 Jan;214(1):27-35. 


Hofer, M., Kormilitzin, A., Goldberg, P. and Nevado-Holgado, A. (n.d.). Few-shot Learning for Named Entity Recognition in Medical Text


Huhn M, Nikolakopoulou A, Schneider-Thoma J, Krause M, Samara M, Peter N, Arndt T, Bäckers L, Rothe P, Cipriani A, Davis J, Salanti G, Leucht S. Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis. Lancet. 2019 Sep 14;394(10202):939-951.


Iqbal E, Govind R, Romero A, Dzahini O, Broadbent M, Stewart R, et al. The side effect profile of Clozapine in real world data of three large mental hospitals. arXiv:200109698 [cs, stat] [Internet]. 2020 Jan 27


Jack RH, Hollis C, Coupland C, Morriss R, Knaggs RD, Cipriani A, Cortese S, Hippisley-Cox J. Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets. Evid Based Ment Health. 2019 Aug;22(3):129-133.


Jones H, Cipriani A. Barriers and incentives to recruitment in mental health clinical trials. Evid Based Ment Health. 2019 May;22(2):49-50.


Kataoka Y, Luo Y, Chaimani A, Onishi A, Kimachi M, Tsujimoto Y, Murad MH, Li T, Cipriani A, Furukawa TA. Cumulative network-meta-analyses, practice guidelines and actual prescriptions of drug treatments for postmenopausal osteoporosis: a study protocol for cumulative network meta-analyses and meta-epidemiological study. BMJ Open. 2018 Dec 4;8(12):e023218.


Kernot C, Tomlinson A, Chevance A, Cipriani A. One step closer to personalised prescribing of antidepressants: using real-world data together with patients and clinicians’ preferences. Evid Based Ment Health. 2019 Aug;22(3):91-92.


Kretzschmar K, Tyroll H, Pavarini G, Manzini A, Singh I, NeurOX Young People’s Advisory Group. Can Your Phone Be Your Therapist? Young People’s Ethical Perspectives on the Use of Fully Automated Conversational Agents (Chatbots) in Mental Health Support. Biomed Inform Insights [Internet]. 2019 Mar; 11: 1-9.


Leucht S, Chaimani A, Mavridis D, Leucht C, Huhn M, Helfer B, Samara M, Cipriani A, Geddes JR, Davis JM. Disconnection of drug-response and placebo-response in acute-phase antipsychotic drug trials on schizophrenia? Meta-regression analysis. Neuropsychopharmacology. 2019 Oct;44(11):1955-1966.


Leucht S, Chaimani A, Leucht C, Huhn M, Mavridis D, Helfer B, Samara M, Cipriani A, Geddes JR, Salanti G, Davis JM. 60 years of placebo-controlled antipsychotic drug trials in acute schizophrenia: Meta-regression of predictors of placebo response. Schizophr Res. 2018 Nov;201:315-323.


Leucht S, Levine SZ, Samara M, Cipriani A, Davis JM, Furukawa TA. Possibly no baseline severity effect for antidepressants versus placebo but for antipsychotics. Why? Eur Arch Psychiatry Clin Neurosci. 2018 Oct;268(7):621-623.


Luo Y, Chaimani A, Kataoka Y, Ostinelli EG, Ogawa Y, Cipriani A, Salanti G, Furukawa TA. Evidence synthesis, practice guidelines and real-world prescriptions of new generation antidepressants in the treatment of depression: a protocol for cumulative network meta-analyses and meta-epidemiological study. BMJ open. 2018 Dec 1;8(12):e023222.


Mavridis D, Salanti G, Furukawa TA, Cipriani A, Chaimani A, White IR. Allowing for uncertainty due to missing and LOCF imputed outcomes in meta?analysis. Statistics in medicine. 2019 Feb 28;38(5):720-37.


McDonald K, Smith T, Broadbent M, Patel R, Geddes JR, Saunders KEA. Prevalence and incidence of clinical outcomes in patients presenting to secondary mental health care with mood instability and sleep disturbance. European Psychiatry. 2020;63(1).


McGowan N, Bilderbeck AC, Goodwin GM, Saunders KEA. Circadian Rest-Activity Patterns in Bipolar Disorder and Borderline Personality Disorder. Translational Psychiatry 9(1) 195 dloc


McKnight RF, de La Motte de Broöns de Vauvert SJGN, Chesney E, Amit BH, Geddes J, Cipriani A. Lithium for acute mania. Cochrane Database Syst Rev. 2019 Jun 1;6:CD004048.


Minichino A, Senior M, Brondino N, Zhang SH, Godwlewska BR, Burnet PWJ, Cipriani A, Lennox BR. Measuring Disturbance of the Endocannabinoid System in Psychosis: A Systematic Review and Meta-analysis. JAMA Psychiatry. 2019 Jun 5.


Nikolakopoulou A, Mavridis D, Furukawa TA, Cipriani A, Tricco AC, Straus SE, Siontis GC, Egger M, Salanti G. Living network meta-analysis compared with pairwise meta-analysis in comparative effectiveness research: empirical study. bmj. 2018 Feb 28;360:k585.


Noma H, Furukawa TA, Maruo K, Imai H, Shinohara K, Tanaka S, Ikeda K, Yamawaki S, Cipriani A. Exploratory analyses of effect modifiers in the antidepressant treatment of major depression: Individual-participant data meta-analysis of 2803 participants in seven placebo-controlled randomized trials. J Affect Disord. 2019 May 1;250:419-424.


Palmius N, Saunders KEA, Carr O, Geddes JR, Goodwin GM, De Vos M. Group- personalized regression models to predict mental health scores from objective mobile phone data stream. Journal of Medical Internet Research 2018 20(10)


Patel S, Saunders KEA. Apps and wearables in the monitoring of mental health disorders. British Journal of Hospital Medicine 2018 79(12): 672-675


Perez Arribas I, Goodwin GM, Geddes JR, Lyons T, Saunders KEA. A signature-based machine learning model for distinguishing bipolar disorder and borderline personality disorder. Transl Psychiatry. 2018 Dec 13;8(1):274.


Salanti G, Chaimani A, Furukawa TA, Higgins JP, Ogawa Y, Cipriani A, Egger M. Impact of placebo arms on outcomes in antidepressant trials: systematic review and meta-regression analysis. International journal of epidemiology. 2018 Jun 6;47(5):1454-64.


Senior M, Burghart M, Yu R, Kormilitzin A, Liu Q, Vaci N, et al. Identifying Predictors of Suicide in Severe Mental Illness: A Feasibility Study of a Clinical Prediction Rule (Oxford Mental Illness and Suicide Tool or OxMIS). Frontiers in Psychiatry. 2020 Apr 15;11.


Shi L, Baird AL, Westwood S, Hye A, Dobson R, Thambisetty M, Lovestone S. A decade of blood biomarkers for Alzheimer’s disease research: an evolving field, improving study designs, and the challenge of replication. Journal of Alzheimer’s Disease. 2018 Jan 1(Preprint):1-8.


Shinohara K, Tanaka S, Imai H, Noma H, Maruo K, Cipriani A, Yamawaki S, Furukawa TA. Development and validation of a prediction model for the probability of responding to placebo in antidepressant trials: a pooled analysis of individual patient data. Evidence-based mental health. 2019 Feb 1;22(1):10-6.


Shinohara K, Efthimiou O, Ostinelli EG, Tomlinson A, Geddes JR, Nierenberg AA, Ruhe HG, Furukawa TA, Cipriani A. Comparative efficacy and acceptability of antidepressants in the long-term treatment of major depression: protocol for a systematic review and networkmeta-analysis. BMJ Open. 2019 May 19;9(5):e027574.


Smith KA, Cipriani A, Hawton KE. Modelling suicide in bipolar disorders: Limitations and opportunities. Bipolar Disord. 2018 Sep;20(6):566-567.


Tomlinson A, Efthimiou O, Boaden K, New E, Mather S, Salanti G, Imai H, Ogawa Y, Tajika A, Kishimoto S, Kikuchi S, Chevance A, Furukawa TA, Cipriani A. Side effect profile and comparative tolerability of 21 antidepressants in the acute treatment of major depression in adults: protocol for a network meta-analysis. Evid Based Ment Health. 2019 May;22(2):61-66.


Tomlinson A, Cipriani A. The times they are a-changin’. Evid Based Ment Health. 2018 Aug;21(3):81.


Tunbridge EM, Narajos M, Harrison CH, Beresford C, Cipriani A, Harrison PJ. Which Dopamine Polymorphisms Are Functional? Systematic Review and Meta-analysis of COMT, DAT, DBH, DDC, DRD1-5, MAOA, MAOB, TH, VMAT1, and VMAT2. Biol Psychiatry. 2019 Oct 15;86(8):608-620.


Vaci N, Koychev I, Kim C-H, Kormilitzin A, Liu Q, Lucas C, et al. Real-world effectiveness, its predictors and onset of action of cholinesterase inhibitors and memantine in dementia: retrospective health record study. The British Journal of Psychiatry [Internet]. [cited 2020 Aug 10];1–7.


Walker S, Potts J, Martos L, Barrera A, Hancock M, Bell S, Geddes J, Cipriani A, Henshall C. Consent to discuss participation in research: a pilot study. Evid Based Ment Health. 2019 Sep 26. pii: ebmental-2019-300116.


Wang, B., Liakata, M., Ni, H., Lyons, T., Nevado-Holgado, A.J., Saunders, K. (2019) A Path Signature Approach for Speech Emotion Recognition. Proc. Interspeech 2019, 1661-1665.


Witt K, Boland A, Lamblin M, McGorry PD, Veness B, Cipriani A, Hawton K, Harvey S, Christensen H, Robinson J. Effectiveness of universal programmes for the prevention of suicidal ideation, behaviour and mental ill health in medical students: a systematic review and meta-analysis. Evid Based Ment Health. 2019 May;22(2):84-90.


Wu S, Gao L, Cipriani A, Huang Y, Yang Z, Yang J, Yu S, Zhang Y, Chai S, Zhang Z, Sun F, Zhan S. The effects of incretin-based therapies on β-cell function and insulin resistance in type 2 diabetes: A systematic review and network meta-analysis combining 360 trials. Diabetes Obes Metab. 2018 Dec 9.


Wu S, Cipriani A, Yang Z, Yang J, Cai T, Xu Y, Quan X, Zhang Y, Chai S, Sun F, Zhan S. .The cardiovascular effect of incretin-based therapies among type 2 diabetes: a systematic review and network meta-analysis. Expert Opin Drug Saf. 2018 Mar;17(3):243-249.


Zhou X, Zhang Y, Furukawa TA, Cuijpers P, Pu J, Weisz JR, Yang L, Hetrick SE, Del Giovane C, Cohen D, James AC, Yuan S, Whittington C, Jiang X, Teng T, Cipriani A, Xie P.  Different Types and Acceptability of Psychotherapies for Acute Anxiety Disorders in Children and Adolescents: A Network Meta-analysis. JAMA Psychiatry. 2019 Jan 1;76(1):41-50.


Zhou X, Liu L, Lan X, Cohen D, Zhang Y, Ravindran AV, Yuan S, Zheng P, Coghill D, Yang L, Hetrick SE, Jiang X, Benoliel JJ, Cipriani A, Xie P. Polyunsaturated fatty acids metabolism, purine metabolism and inosine as potential independent diagnostic biomarkers for major depressive disorder in children and adolescents. Mol Psychiatry. 2019 Oct;24(10):1478-1488.


Zhou X, Cipriani A, Furukawa TA, Cuijpers P, Zhang Y, Hetrick SE, Pu J, Yuan S, Del Giovane C, Xie P. Comparative efficacy and tolerability of new-generation antidepressants for major depressive disorder in children and adolescents: protocol of an individual patient data meta-analysis. BMJ Open. 2018 Jan 5;8(1):e018357.


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