Professor of Translational Neuroscience, University of Oxford
My interests lie in target identification and development in Alzheimer’s disease, taking multiple programmes from discovery to late stage development including in vivo validation and phase II, and in biomarker discovery with two programmes progressed through replication to commercial development.
Underlying all these programmes is a strong element of informatics including high dimensionality data analysis, bioinformatics and clinical informatics.
I am Head of the Translational Neuroscience & Dementia Research group at the University of Oxford’s Department of Psychiatry. We have three main areas of activity, all aiming towards secondary prevention of dementia. By understanding disease mechanisms we seek potential therapeutics; through discovery of biomarkers we hope to enable preventative trials and with informatics we utilise large biological and clinical datasets in the support of translational neuroscience.
In both our mechanisms and biomarkers work we are analysing relatively large datasets using a range of statistical approaches including machine learning. As a consequence of this informaticians and statisticians have come to play an increasingly important role in the group. Building on this expertise, we are now turning attention to datasets beyond genomic and proteomic to clinical and imaging data.
I am lead for the IMI-European Medical Information Framework – Europe’s largest initiative enabling access to research, population and routine care, real world data.