Regulation of RyR2 in the heart and brain

Open to University of Oxford staff.

Type-2 ryanodine receptor (RyR2) mediated calcium release controls the contraction of cardiac myocytes and the excitability of neurons. Consequently, inappropriate activation of RyR2 leads to disease, such as arrhythmias and Alzheimer’s disease. Prof Jones will describe his published and unpublished research examining the pathophysiological regulation of RyR2 in the heart and brain. This spans from single protein super-resolution microscopy, through real time calcium imaging, to in vivo analysis in animal models, and characterisation in human tissue. He will also present data on how targeting RyR2 might offer new treatments for arrhythmias and Alzheimer’s disease.
More information and registration.