The Oxford Precision Psychiatry Lab (OxPPL) is currently working on the following projects.
PETRUSHKA
What does PETRUSHKA stand for?
Personalise antidEpressant TReatment for Unipolar depreSsion combining individual cHoices, risKs and big datA
What is PETRUSHKA?
PETRUSHKA is a project funded by the National Institute of Health Research (NIHR), aimed at developing and subsequently testing a precision medicine approach to the acute pharmacological treatment of major depressive disorder in adults, which can be used in everyday clinical settings.
We will jointly synthesise data from patients with depressive disorder, obtained from diverse datasets, including randomised, observational, real-world studies. Results from this analysis will subsequently inform a web-based platform, which will allow shared decision-making at the individual-patient level during the routine consultation between clinicians and patient.
Protocol
Tomlinson et al., Personalise antidEpressant TReatment for Unipolar depreSsion combining individual cHoices, risKs and big datA (PETRUSHKA): Rationale and Protocol. In press Evid Based Ment Health.
Team
Prof. Andrea Cipriani, Department of Psychiatry, University of Oxford, Oxford, UK: Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford
Dr Anneka Tomlinson, Department of Psychiatry, University of Oxford, Oxford, UK
Dr Orestis Efthimiou, Institute of Social and Preventive Medicine, Bern, Switzerland
Prof. Toshi A Furukawa, Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine/School of Public Health, Kyoto, Japan
Prof. Georgia Salanti, Institute of Social and Preventive Medicine, Bern, Switzerland
Prof. Ilina Singh, Department of Psychiatry, University of Oxford, Oxford, UK
Ms Bessie O’Dell, Department of Psychiatry, University of Oxford, Oxford, UK
Dr Franco De Crescenzo, Department of Psychiatry, University of Oxford, Oxford, UK
GRISELDA
What does GRISELDA stand for?
Group of Researchers Investigating Specific Efficacy of individuaL Drugs for Acute depression.
What is GRISELDA?
A project (network meta-analysis) comparing the efficacy and acceptability of 21 antidepressants used in the acute treatment of depression in adults.
Publication
Cipriani et al. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. Lancet. 2018 Apr 7;391(10128):1357-1366. doi: 10.1016/S0140-6736(17)32802-7. Epub 2018 Feb 21.
Team
Prof. Andrea Cipriani, Department of Psychiatry, University of Oxford, Oxford, UK: Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford
Prof. Toshi A Furukawa, Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine/School of Public Health, Kyoto, Japan
Prof. Georgia Salanti, Institute of Social and Preventive Medicine, Bern, Switzerland
Dr A Chaimani, Institute of Social and Preventive Medicine, Bern, Switzerland
Ms Lauren Atkinson, Department of Psychiatry, University of Oxford, Oxford, UK; Oxford Centre for Human Brain Activity, Department of Psychiatry, Warneford Hospital, Oxford, UK.
Dr Yukeke Ogawa Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine and School of Public Health, Kyoto, Japan.
Prof. Stefan Leucht Department of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany.
Dr Henricus Ruhe Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands.
Dr Erick Turner Behavioral Health and Neurosciences Division, VA Portland Health Care System, Portland, OR, USA; Department of Psychiatry and Department Pharmacology, Oregon Health & Science University, Portland, OR, USA.
Prof. Julian Huggins School of Social and Community Medicine, University of Bristol, Bristol, UK.
Prof Matthias Eggar Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Dr Nozomi Takeshima, Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine and School of Public Health, Kyoto, Japan.
Dr Yu Hayasaka, Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine and School of Public Health, Kyoto, Japan.
Dr Hissei Imai, Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine and School of Public Health, Kyoto, Japan.
Dr Kiyomi Shinohara, Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine and School of Public Health, Kyoto, Japan.
Dr Aran Tajika, Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine and School of Public Health, Kyoto, Japan.
Prof John Iannidis, Department of Medicine, Department of Health Research and Policy, Department of Biomedical Data Science, and Department of Statistics, Stanford University, Stanford, CA, USA; Meta-Research Innovation Center at Stanford, Stanford University, Stanford, CA, USA.
Prof John Geddes Department of Psychiatry, University of Oxford, Oxford, UK: Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford
GRISELDA Update
Prof. Andrea Cipriani, Department of Psychiatry, University of Oxford, Oxford, UK: Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford
Prof. Toshi A Furukawa, Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine/School of Public Health, Kyoto, Japan
Dr Anneka Tomlinson, Department of Psychiatry, University of Oxford, Oxford, UK
Dr Orestis Efthimiou, Institute of Social and Preventive Medicine, Bern, Switzerland
Ms Katharine Boaden, Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford
MARTHA
What does MARTHA stand for?
Meta-Analysis of Relative Tolerability and Harms of Antidepressant
What is MARTHA?
The MARTHA project is a network meta-analysis and standard meta-analysis comparing the tolerability of 21 antidepressants used in the acute treatment of depression in adults. This project examines all the individual adverse events (side effects) of the 21 antidepressants including the frequently occurring and rare adverse events.
Protocol
Tomlinson et al,. Side effect profile and comparative tolerability of 21 antidepressants in the acute treatment of major depression in adults: protocol for a network meta-analysis. Evid Based Ment Health. 2019 May;22(2):61-66. doi: 10.1136/ebmental-2019-300087. Epub 2019 Apr 17.
Prospero
https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=128141
Team
Dr Anneka Tomlinson, Department of Psychiatry, University of Oxford, Oxford, UK
Dr Orestis Efthimiou, Institute of Social and Preventive Medicine, Bern, Switzerland
Ms Katharine Boaden, Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford
Ms Emma New, Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford
Ms Sarah Mather, Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford
Prof. Georgia Salanti, Institute of Social and Preventive Medicine, Bern, Switzerland
Dr Hissei Imai, Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine/School of Public Health, Kyoto, Japan
Dr Yusuke Ogawa, Department of Healthcare Epidemiology, Kyoto University Graduate School of Medicine, Kyoto, Japan
Dr Aran Tajika, Department of Psychiatry, Kyoto University Hospital, Kyoto, Japan
Dr Sanae Kishimoto, Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine/School of Public Health, Kyoto, Japan
Dr Sino Kikuchi, Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine/School of Public Health, Kyoto, Japan
Dr Astrid Chevance, Paris Descartes University, Paris, France; METHODS Team, Center for Research in Epidemiology and Statistics, Sorbo
Prof. Toshi A Furukawa, Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine/School of Public Health, Kyoto, Japan
Prof. Andrea Cipriani, Department of Psychiatry, University of Oxford, Oxford, UK: Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford
NATALIA
What does NATALIA stand for?
Network meta-Analysis Targeting Antidepressant Long term effects In Adults with depression
What is NATALIA?
The NATALIA project follows on from GRISELDA, which focused on the acute treatment of depression. It is important that we complete the story and investigate the longer-term effects of antidepressants in adults. A project using a pairwise meta-analysis and a network meta-analysis (NMA) to examine the relative efficacy, tolerability and acceptability of antidepressants in the long-term treatment of major depression.
Protocol
Shinohara et al., Comparative efficacy and acceptability of antidepressants in the long-term treatment of major depression: protocol for a systematic review and network meta-analysis. BMJ Open. 2019 May 19;9(5):e027574. doi: 10.1136/bmjopen-2018-027574.
Team
Prof. Toshi A Furukawa, Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine/School of Public Health, Kyoto, Japan
Prof. Andrea Cipriani Department of Psychiatry, University of Oxford, Oxford, UK; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford
Dr Anneka Tomlinson, Department of Psychiatry, University of Oxford, Oxford, UK
Dr Kiyomi Shinohara, Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine/School of Public Health, Kyoto, Japan
Dr Orestis Efthimiou, Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
Dr Edoardo G Ostinelli, Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine/School of Public Health, Kyoto, Japan
Dr Andrew A Nierenberg, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, US
Dr Henricus G Ruhe, Department of Psychiatry, Radboud University, Nijmegen, the Netherlands
Ms Katharine Boaden, Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford
Prof. John R Geddes, Department of Psychiatry, University of Oxford, Oxford, UK; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford
SUSANA
What does SUSANA stand for?
Survey to Understand the Side effects of ANtidepressants in Adults
What is SUSANA?
The SUSANA survey is a designed with the intention to collect data from thousands of patients and prescribers, SUSANA will enable us to identify and rank the most common side effects of antidepressants, based on how troublesome and impairing they can be for patients in the real world Read more about SUSANA here.
Protocol
Tomlinson et al., Side effect profile and comparative tolerability of 21 antidepressants in the acute treatment of major depression in adults: protocol for a network meta-analysis. Evid Based Ment Health. 2019 May;22(2):61-66. doi: 10.1136/ebmental-2019-300087. Epub 2019 Apr 17.
Team
Dr Anneka Tomlinson, Department of Psychiatry, University of Oxford, Oxford, UK
Dr Orestis Efthimiou, Institute of Social and Preventive Medicine, Bern, Switzerland
Dr Astrid Chevance, Paris Descartes University, Paris, France; METHODS Team, Center for Research in Epidemiology and Statistics, Sorbo
Prof. Toshi A Furukawa, Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine/School of Public Health, Kyoto, Japan
Prof. Andrea Cipriani, Department of Psychiatry, University of Oxford, Oxford, UK: Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford
