Precision medicine in psychiatry – a focus on treatment prediction in depression: a meta-review
Summary
This is a meta-review to identify individual predictors of treatment effect of pharmacological, psychological, electroconvulsive and neuromodulatory treatments in unipolar depression. We also aim to identify, catalogue and evaluate clinical prediction models of treatment effect with a specific focus in unipolar depression, complemented by a non-systematic exploration of clinical prediction models used in other fields.
Team
Andrea Cipriani, Department of Psychiatry, University of Oxford, Oxford, UK: Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford
Orestis Efthimiou, Institute of Social and Preventive Medicine, Bern, Switzerland
George Gillet, Department of Psychiatry, University of Oxford, Oxford, UK
Anneka Tomlinson, Department of Psychiatry, University of Oxford, Oxford, UK
Protocol
Gillet et al., Precision medicine in psychiatry – a focus on treatment prediction in depression: a meta review
Prospero
https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=141425
Sleep deprivation as a treatment for major depressive episodes: a systematic review and meta-analysis
Summary
To assess the efficacy, acceptability and tolerability of sleep deprivation in comparison to any other intervention for the acute and long-term treatment of major depressive episodes in unipolar or bipolar affective disorders.
Team
Andrea Cipriani, Department of Psychiatry, University of Oxford, Oxford, UK: Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford
Franco De Crescenzo, Department of Psychiatry, University of Oxford, Oxford, UK
John Geddes, Department of Psychiatry, University of Oxford, Oxford, UK: Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford
Simon Kyle, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
Pamina Mitter, Department of Psychiatry, University of Oxford, Oxford, UK: Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford
Anneka Tomlinson, Department of Psychiatry, University of Oxford, Oxford, UK
Protocol
Mitter et al., Sleep deprivation as a treatment for major depressive episodes: a systematic review and meta-analysis
Prospero
Under review
Informing National Health Service patients about participation in clinical research: A comparison of opt-in and opt-out approaches across the United Kingdom
Summary
Recruitment to clinical research in the National Health Service remains challenging. One barrier is accessing patients to discuss research participation. Two general approaches are used in the United Kingdom to facilitate this: an ‘opt-in’ approach (when clinicians communicate research opportunities to patients) and an ‘opt-out’ approach (all patients have the right to be informed of relevant research opportunities). No evidence-based data are available, however, to inform the decision about which approach is preferable. This study aimed to collect information from ‘opt-in’ and ‘opt-out’ Trusts and identify which of the two approaches is optimal for ensuring National Health Service patients are given opportunities to discuss research participation.
Team
Andrea Cipriani, Department of Psychiatry, University of Oxford, Oxford, UK; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK
Nick Broughton, Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK
Roger Ede, Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK
John R Geddes, Department of Psychiatry, University of Oxford, Oxford, UK; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK
Mark Hancock, Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK
Catherine Henshall, Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK; Faculty of Health and Life Sciences, Oxford Brookes University, Oxford, UK
Catherine Kernot, Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK
Lorcan O’Neill, Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK
Jennifer Potts, Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK
Mark Underwood, Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK
Sophie Walker, Department of Psychiatry, University of Oxford, Oxford, UK; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK
Ketamine and other glutamate receptor modulators for depression in adults: Cochrane Review
Summary
- An update to Caddy et al. (2015), with the following aims:
- To assess the effects of ketamine and other glutamate receptor modulators in alleviating the acute symptoms of depression in people with unipolar major depressive disorder.
- To review the acceptability of ketamine and other glutamate receptor modulators in people with unipolar major depressive disorder.
- To investigate the adverse effects of ketamine and other glutamate receptor modulators in people with unipolar major depressive disorder.
Team
Andrea Cipriani, Department of Psychiatry, University of Oxford, Oxford, UK; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK
Annabelle Barnes, Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK
Phil Cowen, Department of Psychiatry, University of Oxford, Oxford, UK; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK
Rebecca Dean, Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK
Keith Hawton, Centre for Suicide Research, Department of Psychiatry, University of Oxford, Oxford, UK; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK
Sarah Hollingsworth, Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK
Claudia Hurducas, Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK
Tahnee Marquardt, Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK
Rupert McShane, Radcliffe Department of Medicine, University of Oxford, Oxford, UK
Rebecca Smith, Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK
Stella Spyridi, Department for Rehabilitation Sciences, Cyprus University of Technology
Erick Turner, Portland Veterans Affairs Medical Center, Portland, USA
Ketamine and other glutamate receptor modulators for depression in bipolar disorder in adults: Cochrane Review
Summary
- An update to McCloud et al. (2015), with the following aims:
- To assess the effects of ketamine and other glutamate receptor modulators in alleviating the acute symptoms of depression in people with bipolar disorder.
- To review the acceptability of ketamine and other glutamate receptor modulators in people with depression and bipolar disorder.
- To investigate the adverse effects of ketamine and other glutamate receptor modulators in people with depression and bipolar disorder.
Team
Andrea Cipriani, Department of Psychiatry, University of Oxford, Oxford, UK; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK
Annabelle Barnes, Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK
Phil Cowen, Department of Psychiatry, University of Oxford, Oxford, UK; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK
Rebecca Dean, Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK
Keith Hawton, Centre for Suicide Research, Department of Psychiatry, University of Oxford, Oxford, UK; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK
Sarah Hollingsworth, Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK
Claudia Hurducas, Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK
Tahnee Marquardt, Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK
Rebecca Smith, Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK
Stella Spyridi, Department for Rehabilitation Sciences, Cyprus University of Technology
